Bone Abstracts

A 29 week pre-term female infant, Molly (not real name), was referred to our multi-disciplinary Metabolic Bone Disease Service at the age of 19 months, with a combined diagnosis of inherited osteogenesis imperfecta (OI) and cerebral palsy (CP) spastic quadriplegia, resulting from a intra-ventricular haemorrhage at 7 weeks-old.Diagnosis of OI was confirmed at birth following fractures. Molly was treated with IV Pamidronate from the age of 6 weeks at a loc...

Patients with moderate to severe osteogenesis imperfecta commonly have functional difficulties following fractures or surgery, which generally result in long periods of immobility. Patients quickly lose range of movement, muscle strength and conditioning, which impacts on daily living activities, mobility, self-confidence and motivation. It is natural for patients to become more dependent on their carers, some not returning to their previous level of independence, nor achievin...